On January 9, 2026, the European Commission released a draft proposal to technically update Annex XVII of the REACH Regulation. This aims to align with the new hazard classifications added under the CLP Regulation in 2024 and 2025. The core amendments involve expanding the list of restricted Carcinogenic, Mutagenic or Toxic for Reproduction (CMR) substances.
Key Updates
Appendix 1 (Carcinogens: Category 1A)
|
New Substance |
EC No |
CAS No |
|
Vinyl fluoride |
200-832-6 |
75-02-5 |
Appendix 2 (Carcinogens: Category 1B)
|
New Substance |
EC No |
CAS No |
|
Multi-walled carbon tubes (synthetic graphite in tubular shape) with a geometric tube diameter range ≥ 30 nm to < 3 μm and a length ≥ 5 μm and aspect ratio > 3:1, including multi-walled carbon nanotubes, MWC(N)T |
– |
– |
|
Acetone oxime |
204-820-1 |
127-06-0 |
|
Benthiavalicarb-isopropyl (ISO); isopropyl [(S)-1-{[(R)-1-(6-fluoro-1,3-benzothiazol-2-yl)ethyl]carbamoyl}-2-methylpropyl]carbamate |
– |
177406-68-7 |
|
1,4-Dichloro-2-nitrobenzene |
201-923-3 |
89-61-2 |
|
Trimethyl phosphate |
208-144-8 |
512-56-1 |
|
Barium chromate |
233-660-5 |
10294-40-3 |
|
1,1-dichloroethylene; vinylidene chloride |
200-864-0 |
75-35-4 |
Appendix 4 (Germ cell mutagens: Category 1B)
|
New Substance |
EC No |
CAS No |
|
N,N′-Methylenediacrylamide |
203-750-9 |
110-26-9 |
|
Trimethyl phosphate |
208-144-8 |
512-56-1 |
Appendix 6 (Reproductive toxicants: Category 1B)
|
New Substance |
EC No |
CAS No |
|
Trimethyl borate |
204-468-9 |
121-43-7 |
|
Perboric acid, sodium salt [1] Perboric acid, sodium salt, monohydrate [2] Perboric acid (HBO(O₂)), sodium salt, monohydrate [3] Sodium peroxoborate [4] Sodium perborate [5] |
234-390-0 [1] 234-390-0 [2] - [3] -[4] 239-172-9 [5] |
11138-47-9 [1] 12040-72-1 [2] 10332-33-9 [3] - [4] 15120-21-5 [5] |
|
Perboric acid (H₃BO₂(O₂)), monosodium salt trihydrate [1] Perboric acid, sodium salt, tetrahydrate [2] Perboric acid (HBO(O₂)), sodium salt, tetrahydrate [3] Sodium peroxoborate, hexahydrate [4] |
239-172-9 [1] 234-390-0 [2] - [3] - [4] |
13517-20-9 [1] 37244-98-7 [2] 10486-00-7 [3] - [4] |
|
Sodium peroxometaborate |
231-556-4 |
7632-04-4 |
|
Reaction mass of 1,3-dioxan-5-ol and 1,3-dioxolan-4-ylmethanol |
– |
– |
|
2-(Dimethylamino)-2-[(4-methylphenyl)methyl]-1-[4-(morpholin-4-yl)phenyl]butan-1-one |
438-340-0 |
119344-86-4 |
|
Sodium 3-(allyloxy)-2-hydroxypropanesulphonate |
258-004-5 |
52556-42-0 |
|
Tert-butyl 2-ethylperoxyhexanoate |
221-110-7 |
3006-82-4 |
|
Dinitrogen oxide (N₂O) |
233-032-0 |
10024-97-2 |
|
Trimethyl phosphate |
208-144-8 |
512-56-1 |
|
2-Bromo-3,3,3-trifluoroprop-1-ene |
– |
1514-82-5 |
|
2,3-Epoxypropyl isopropyl ether |
223-672-9 |
4016-14-2 |
|
α,α'-Propylenedinitrilodi-o-cresol |
202-374-2 |
94-91-7 |
|
2-Ethylhexanoic acid, monoester with propane-1,2-diol |
285-503-5 |
85114-00-7 |
|
Tetrahydrofurfuryl methacrylate |
219-529-5 |
2455-24-5 |
|
9-Octadecenoic acid (Z)-, sulfonated, potassium salts [1] Reaction products of fatty acids, C18 (unsaturated) alkyl with sulfur trioxide, potassium salts [2] 9(Or 10)-sulphooctadecanoic acid, potassium salt [3] |
271-843-1 [1] - [2] 267-966-5 [3] |
68609-93-8 [1] - [2] 67968-63-2 [3] |
This draft is currently open for public consultation. The deadline for submitting comments is February 6, 2026. Once adopted, the regulation will enter into force 20 days after its publication in the Official Journal of the European Union.
You can freely access the EU CMR substances list via the provided link:
https://www.chemradar.com/tools/cis/inv/6593b44205b53d5bc391a5c8?utm_medium=gcis&utm_campaign=cis
