On October 15, 2026, the U.S. Environmental Protection Agency (EPA) published a final rule in the Federal Register, establishing Significant New Use Rules (SNURs) for 19 chemical substances under the Toxic Substances Control Act (TSCA). The substances cover various categories, including organosilicon compounds, polyurethane raw materials, polymers, and semiconductor photoresist materials. This rule will officially take effect on December 14, 2026.
Summary Table of Substances Subject to SNUR
|
No. |
Substance Name |
PMN Number |
CASRN/Login No. |
|
1 |
6-Octen-1-ol, 3,7-dimethyl-, homopolymer, monoacetate |
P–20–174 |
2417284–25–2 |
|
2 |
Alkyl dicarboxylic acid, branched dialkyl ester (generic name) |
P–21–104 |
303674 |
|
3 |
Alkyl dicarboxylic acid, di C11–14 isoalkyl ester (generic name) |
P–21–105 |
303663 |
|
4 |
Siloxanes and Silicones, di-Me, [alkylpiperazinium-hydroxyalkoxy]alkyl terminated, aryl sulfonate (salt) (generic name) |
P–21–166 |
— |
|
5 |
Siloxanes and Silicones, di-Me, bis-terminated, polyethylene glycol alkyl ether etherified, aryl sulfonate (salt) (generic name) |
P–21–167 |
— |
|
6 |
Polymer of soybean oil with diethylene glycol/glycerin/tetraethylene glycol/triethylene glycol and PET waste plastic depolymerizates, etc. |
P–23–78 |
2803562–50–5 |
|
7 |
Benzoic acid, 2-([1,1′-biphenyl]-4-carbonyl)-, 2-ethylhexyl ester |
P–23–138 |
75005–95–7 |
|
8 |
Ethyl modified lactam (generic name) |
P–23–183 |
— |
|
9 |
Polymer of substituted carbon polycyclic dicarboxylic acid dialkyl ester with alkanediol, etc. (generic name) |
P–23–193 |
— |
|
10 |
Acrylic polymer salt (containing sodium acrylamido-methylpropane sulfonate, etc.) (generic name) |
P–24–6 |
303721 |
|
11 |
2-Propanamine, N,N′-(oxydi-2,1-ethanediyl)bis[N-methyl-] |
P–24–16 |
2484716–03–0 |
|
12 |
Hydrolysis product of polyalkyl substituted amine with alkenyl trialkoxy metal compound and silica (generic name) |
P–24–20 |
— |
|
13 |
Alkanol, alkoxyalkyl imino, salt (generic name) |
P–24–46 |
— |
|
14 |
Alkanol, nitrilo, salt (generic name) |
P–24–47 |
— |
|
15 |
Polymer of aryl dicarboxylic acid with alkyl dicarboxylic acid, etc. (containing polymethylene polyphenyl isocyanate) (generic name) |
P–24–70 |
— |
|
16 |
Diaryl carbonate with alkanediol (generic name) |
P–24–105 |
— |
|
17 |
1,3-Butanediol, 4,4,4-trifluoro-3-(trifluoromethyl)- |
P–24–114 |
21379–33–9 |
|
18 |
Sulfonium salt (trisubstituted carbon monocyclic) substituted oxatricyclic alkyl oxycarbonyl dihaloalkane sulfonate (generic name) |
P–25–106 |
— |
|
19 |
Heteromonocyclic alkyl substituted carbon monocyclic carbon polycyclic heteromonocyclic dihalosulfoacetate (generic name) |
P–25–107 |
— |
Key Control Types
- Workplace Protection (§721.63): Most require engineering controls and respiratory protection (some require NIOSH APF ≥ 1000).
- Hazard Communication (§721.72): Involves health warnings for specific target organ toxicity, skin/eye irritation, sensitization, reproductive toxicity, acute toxicity, genotoxicity, etc.
- Industrial/Commercial/Consumer Activity Restrictions (§721.80): Includes restrictions on inhalation exposure, use only in liquid solution, concentration limits, and restrictions to specific applications (e.g., two-component polyurethane spray foam catalysts, construction sealant foams, semiconductor photolithography).
- Water Release Restrictions (§721.90): Sets N-values (release control indicators) for various substances.
- Other Restrictions: Individual substances may also involve disposal restrictions (§721.85) and particle size restrictions (e.g., ≥ 2.5 mm).
ChemRadar Insights
According to the rule released this time, relevant enterprises and individuals must submit a Significant New Use Notice (SNUN) to the EPA at least 90 days before engaging in any activity deemed a "significant new use" for these substances—including manufacturing (including importing), processing, using, distributing in commerce, or disposing. Related activities must not commence until the EPA completes its review and makes a determination.
The final regulations for these SNURs present clear compliance challenges for chemical and related supply chain enterprises. Companies should immediately initiate internal screening to confirm whether the chemicals they produce, import, or process fall within the scope of the control list, and assess whether existing uses cross the "significant new use" red line.
CIRS Services
- TSCA Inventory and Confidential Inventory Inquiry
- Response strategies for existing substances listed on the TSCA Inventory
- Pre-manufacture Notice (PMN) Exemptions (substances regulated by other statutes, substances for R&D, low volume substances, polymers, etc.)
- Pre-manufacture Notices (PMNs)
- Significant New Use Notices (SNUNs)
