On August 11, 2025, the European Commission formally adopted Commission Regulation (EU) 2025/1731, amending Annex XVII of the Registration, Evaluation, Authorization, and Restriction of Chemicals (REACH) Regulation to strengthen controls over Carcinogenic, Mutagenic, or Reproductive Toxic (CMR) substances.
Key Amendments
The following 16 CMR substances have been added to REACH Annex XVII:
|
Substances |
EC No |
CAS No |
Hazard Classification |
|
‘diuron (ISO); 3-(3,4-dichlorophenyl)-1,1-dimethylurea |
206-354-4 |
330-54-1 |
Carcinogen Category 1B |
|
‘2,2',6,6'-tetrabromo-4,4'-isopropylidenediphenol; tetrabromobisphenol-A |
201-236-9 |
79-94-7 |
Carcinogen Category 1B |
|
‘N,N-dimethyl-p-toluidine |
202-805-4 |
99-97-8 |
Carcinogen Category 1B |
|
‘4-nitrosomorpholine |
- |
59-89-2 |
Carcinogen Category 1B |
|
‘4-methylimidazole |
212-497-3 |
822-36-6 |
Carcinogen Category 1B, Reproductive Toxicity Category 1B |
|
‘dimethyl propylphosphonate |
242-555-3 |
18755-43-6 |
Mutagen Category 1B, Reproductive Toxicity Category 1B |
|
‘diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide |
278-355-8 |
75980-60-8 |
Reproductive Toxicity Category 1B |
|
‘benzyl(diethylamino)diphenylphosphonium 4-[1,1,1,3,3,3-hexafluoro-2-(4-hydroxyphenyl)propan-2-yl]phenolate |
479-100-5 |
577705-90-9 |
Reproductive Toxicity Category 1B |
|
‘benzyltriphenylphosphonium, salt with 4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]bis[phenol] (1:1) |
278-305-5 |
75768-65-9 |
Reproductive Toxicity Category 1B |
|
‘reaction mass of 4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]diphenol and benzyl(diethylamino)diphenylphosphonium 4-[1,1,1,3,3,3-hexafluoro-2-(4-hydroxyphenyl)propan-2-yl]phenolate (1:1) |
- |
- |
Reproductive Toxicity Category 1B |
|
‘reaction mass of 4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]diphenol and benzyltriphenylphosphonium, salt with 4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]diphenol (1:1) |
- |
- |
Reproductive Toxicity Category 1B |
|
‘dibutyltin maleate |
201-077-5 |
78-04-6 |
Reproductive Toxicity Category 1B |
|
‘dibutyltin oxide |
212-449-1 |
818-08-6 |
Reproductive Toxicity Category 1B |
|
‘reaction mass of 1-(2,3-epoxypropoxy)-2,2-bis ((2,3-epoxypropoxy)methyl) butane and 1-(2,3-epoxypropoxy)-2-((2,3-epoxypropoxy)methyl)-2-hydroxymethyl butane |
- |
- |
Reproductive Toxicity Category 1B |
|
‘4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]diphenol; bisphenol AF |
216-036-7 |
1478-61-1 |
Reproductive Toxicity Category 1B |
|
‘1,4-Benzenediamine, N,N’-mixed Ph and tolyl derivs.; |
273-227-8 |
68953-84-4 |
Reproductive Toxicity Category 1B |
Derogations
|
Substances |
CAS No
|
EC No |
Derogations |
|
Cumene |
98-82-8 |
202-704-5 |
As a substance on its own or as a constituent of other substances in either of the following: (a) kerosene used as aviation fuel conforming to DEF STAN 91-091, ASTM specification D1655 or equivalent recognised standards and marketed under descriptions such as Jet-A, Jet-A1 or JP-(x); (b) gasoline used as aviation fuel conforming to DEF STAN 91-090, ASTM D910, ASTM D7547 or equivalent recognised standards. |
Regulatory Timeline
Restrictions on the new Category 1B CMR substances will officially take effect on September 1, 2025, and apply directly across all EU member states.
Further Information
