On July 7, 2025, the European Chemicals Agency (ECHA) initiated a public consultation regarding proposals for the harmonized classification and labelling (CLH) of two substances. Feedback is open until September 5, 2025. On the same day, ECHA also introduced 16 new testing proposals for substances, inviting public comments by August 21.
CLH Proposals
| l-p-mentha-1(6),8-dien-2-one; (5R)-2-methyl-5-(prop-1-en-2-yl)cyclohex-2-en-1-one; l-carvone | 229-352-5 | 6485-40-1 | Explosives Flammable liquids Self-reactive substances and mixtures Pyrophoric liquids Self-heating substances Substances which in contact with water emit flammable gases Oxidising liquids Organic peroxides Corrosive to metals Acute toxicity via oral route Acute toxicity via dermal route Acute toxicity via inhalation route Skin corrosion/irritation Serious eye damage/eye irritation Skin sensitisation Germ cell mutagenicity Carcinogenicity Reproductive toxicity Specific target organ toxicity-single exposure Specific target organ toxicity-repeated exposure Aspiration hazard Hazardous to the aquatic environment Hazardous for the ozone layer |
07/07/2025 | 05/09/2025 |
| Spearmint oil; Essential oil of Spearmint obtained from the aerial part of Mentha spicata and/or Mentha cardiaca (Lamiaceae) obtained by distillation | - | 8008-79-5 | Explosive Flammable liquid Pyrophoric liquid Self-heating substance or mixture Substance or mixture which in contact with water emits flammable gas Oxidising liquid Acute toxicity Skin corrosion/irritation Serious eye damage/eye irritation Skin sensitisation Germ cell mutagenicity Carcinogenicity Reproductive toxicity Specific target organ toxicity — single exposure Specific target organ toxicity — repeated exposure Aspiration hazard Hazardous to the aquatic environment Hazardous for the ozone layer |
07/07/2025 | 05/09/2025 |
The CLH process aims to ensure consistency and transparency in hazard information for chemicals across Europe. This procedure involves assessing the hazardous properties of chemical substances, proposing appropriate classifications and labels, collecting public input, and concluding with a final review and recommendations by ECHA's Committee for Risk Assessment (RAC).
Testing Proposals
| Benzenamine, N-phenyl-, reaction products with 2,4,4-trimethylpentene | 270-128-1 | 68411-46-1 |
21/08/2025
21/08/2025
21/08/2025
|
6.1.2 Long-term toxicity to fish
7.8.2 Developmental toxicity / teratogenicity (species: rat)
7.8.2 Developmental toxicity / teratogenicity (species: rabbit)
|
| N,N,N',N'-tetramethyl-2,2'-oxybis(ethylamine) | 221-220-5 | 3033-62-3 |
21/08/2025
21/08/2025
21/08/2025
|
6.1.2 Long-term toxicity to fish
7.8.1 Toxicity to reproduction
7.8.2 Developmental toxicity / teratogenicity
|
| Dibutyl [[bis[(2-ethylhexyl)oxy]phosphinothioyl]thio]succinate | 270-220-1 | 68413-48-9 |
21/08/2025
21/08/2025
|
7.5.1 Repeated dose toxicity: oral
7.8.2 Developmental toxicity / teratogenicity
|
| diethyl ether | 200-467-2 | 60-29-7 | 21/08/2025 | 7.8.1 Toxicity to reproduction |
| Methyl-1h-benzotriazole | 249-596-6 | 29385-43-1 | 21/08/2025 | 7.8.2 Developmental toxicity / teratogenicity||Note: testing proposed with 5-methyl-1H-benzotriazole (EC no. 205-265-8) and 4-methyl-1H-benzotriazole (EC no. 249-921-1) |
| N-(2-ethylhexyl)-1-[[2-methyl-4-[(2-methylphenyl)azo]phenyl]azo]naphthalen-2-amine | 260-124-8 | 56358-09-9 | 21/08/2025 | 7.6.2 Genetic toxicity in vivo |
| Oils, vegetable, sulfonated, sodium salts | 307-044-2 | 97489-04-8 | 21/08/2025 | 6.1.2 Long-term toxicity to fish||Note: testing proposed with Oils, fish, oxidized, bisulfited, sodium salts (EC no. 307-037-4) |
| Potassium trifluorozincate | 237-537-7 | 13827-02-6 | 21/08/2025 | 6.1.2 Long-term toxicity to fish |
| Reaction product of p-nonylphenol, formaldehyde and diethanolamine, propoxylated | 701-426-6 | - | 21/08/2025 | 6.1.2 Long-term toxicity to fish |
| Sodium 4(or 5)-methyl-1H-benzotriazolide | 265-004-9 | 64665-57-2 | 21/08/2025 | 7.8.2 Developmental toxicity / teratogenicity||Note: testing proposed with 5-methyl-1H-benzotriazole (EC no. 205-265-8) and 4-methyl-1H-benzotriazole (EC no. 249-921-1) |
| Tetrasodium 7,7'-(carbonyldiimino)bis[4-hydroxy-3-[(6-sulphonato-2-naphthyl)azo]naphthalene-2-sulphonate] | 249-171-5 | 28706-25-4 | 21/08/2025 | 6.1.2 Long-term toxicity to fish |
Under the REACH regulation, prior to conducting studies listed in Annexes IX and X (corresponding to registration tonnages of 100–1,000 t/y and above 1,000 t/y), registrants are required to submit testing proposals (TPs). After the public consultation period ends, ECHA will finalize testing requirements based on the feedback received and the specific characteristics of the substances. By soliciting public input, ECHA seeks to optimize safety assessments and revise testing requirements accordingly. Registrants must carry out these tests and update safety documentation to ensure the safe use of chemicals and promote sustainable development within the industry.
Further Information
